Baquade’s way of working

Basqüadé acts this way:

a) Inhibition of tumoral cells growth.

b) Causing a programmed cell death.

c) Acting as inmunomodulator.

Studies with Basquade’s components in Southamerican and European countries in citotoxicity tests determined interactions of these with the DNA of the tumoral cells (pro-oxidation) and some good results in leuchemia (Arizona, M. et al., 1985; Jorbis B. et al., 1988, Mangelli E. et al., 1996).

Among the biological activities shown by the components of Basquade it can be mentioned at the digestive level the anti-ulcer activity based on a smaller movilization of calcium at the inter.-cell level (Gamberini and Lapa A.1992) and the liver-protective and colagoge action shown by its flavonoids. They showed to increment between a 25% and a 100% the percentage of outlivng in intoxicated rats with phalloidine in a 20 mg/kg intravenous dose.

In tests done with rodents the substance that showed to be more effective was the hispiduline (flavonoid), active principle in Basquade, according to studies done by Soickee H. And Leng Peschlow E. In 1987.

Action in malignant prostate neoplasias

According to the experience gathered there is a benefitial effect of Basquade over the prostatic neoplasias, that is shown:

1) Normalizing or diminishing the PSA

2) Causing a loss in the tumors’ size

3) Causing changes over the consistency that changes from stony to woody and from woody to normal prostate consistency. This particular reversion in the histology of the prostate is given by the synergism resultant of the interaction between the active principles of Basquade’s components, that result harmful for the tumor.

Because of the apoptosis caused by Basquade’s action, we found pieces of prostatectomies with important intratumorals necrosis and haemorrhage about to be resolved or organizing. This wouldn’t correspond to the observation as much as with the convencional hormonal treatment generally used.

It has been see also that Basquade prevents the creation of new tumoral clones that escape to the control of the organism and that could cause an early metastatization mainly on the bone substance because prostatic metastasi are eager for the bones.

Thus, Basquade exerts a protective action at the bone level preventing toe colonization of this sector. Boneblastic injuries treated with Basquade back down and are excreted by the organic purge systems, causing a dismiss and movilzation of the accumulated substance in the skeleton or particular areas of this.

Exploring with bone tests allows to appreciate the differences between treatments befote and alter Basquade. Traditional hormonal therapy has the risk of causing thrombotic pathology.This is another effect that we don’t notice with Basquade, when it is faced a conventional treatment with Basquade it is benefitial because it frees the patients of thrombus in the lower members and other areas.

Action in renal neoplasias

Basquade’s action on kidney’s neoplasias is highly specific, actino in a selective way over the tumoral cell, having no side effects on the benign cells. Basically it has a pattern of action similar to the one seen in the prostate.There would be an inhibition of the tumoral neoangiogenesis, leaving the tumor withouth nutrients, inhibition of metastatic production by blocking receptors in different areas of the economy and by litic direct action over the metastatic cell.

Acting on the membrane potentials achieving a wide cell permeability, thus the apoptosis is produced. Many times it is possible to take the tumoral cells to cinetics zero, to a state of no reproduction, no proliferation, staying thus the tumor/s stable for years, without growing in all that time, without dissapearing either but keeping the patient without any symptoms and with excelent quality of life.

Action in malignant neoplasias of colon and rectum

Basquade’s action on the colon-rectum neoplasias is basically mediated by the mechanisms already exponed in other neoplasias.
The malignant pathology is developed by many exogen carcinogens (bacause of the diet) and endogens (gradual trnsformationof benign polyps in malignant neoplasias).

Basquade could take malignant cells to a reproductive phase zero preventing the carcinogenesis, keeping the tumor/s in a non proliferative phase and preventing thus the cancerization in these areas. It causes also a purge of the toxins at the colo-rectal level taking a toxins “clearing” that harm and help the carinogenesis.
Its inmunomodulating action prevents from infections and viral colonizations that could lead to the development of a neoplasia.
Basquade can acto together with chimiotherapy also in this pathology because its action is innocuous, without medicine interactions and without side effects.

Action in broncho- pulmonary carcinome with metastasis

Basquade acts according to the mechanisms already explained.
Basqüadé acts stimulating the ciliar clearing and thus helping the purge of toxic substances that can locate in the bronchial-alveolous tree. It has a smoke cleaning action either tobacco or other type, diminishing tar and nicotine absorbed at the bronchial-lung level.

Because of it anti-infectious activity, it protects the lungs of repeated infections that can cause a fertile terrain for CBP. Besides, its inmuno-estimulant action acts synergically in this way. When because of pleural colonization there is pleural shedding, Basquade acts at that level causing reabsortion of the liquid, changing its viscosity, making it easier to extract by evacuating thorax-centesis.

This liquid can have malignant cells or not, but is is a complication that bothers the patient because it may cause respiratory insufficiency.

As it acts on the hematosis, it achieves that the hemoglobine transports more oxygen to the tissues and this is of vital importance in patients with a compromising ventilation. About encephalic metastasi its action is according to what we exposed for the central nervous system taking into account that the most common tumors in this system are metastasic and one of the metastizers in this system is the CBP. It also acts over the suprarenal metastasis by a cytotoxic mechanism that we think is direct at the cell level.

Action in pancreas neoplasias

Pancreatic tumors can be of the exogen or endogen pancreas, with this we refer to the cells that can be affected by a neoplasia. The ones of exogen secretion for instance: head pancreas tumor or the ones of endogen secretion (insulinoma). It is very important the analgesic effect tha Basquade possess and that is shown in this type of neoplasias in a very clear way. Generally, pancreatic tumors (specially the exogen pancreas’) compromise because of its location the solar plex, causing pain that could be really impossible to treat even with a full morphine dose.

Basquade inhibits the secretion of inflammation mediating substances and prostaglandinas so it relieves the important pain that these pathologies cause.
Because it has a inmunoestimulant effect, it delays the neoplasic caquexia, so characterisitc in these tumors. Generally, it delays the appearance of hepatic metastasi and the sticking of the tumor to big neigbour vessels.

In endogen tumors it acts by the already known mechanisms and prevents susbtances like the insulina (insulinota) to be released or like in the gastrinome that produces a perverse release of gastrine.

Action in thyroid neoplasias

Thyroid tumors, either papilars, folicualrs, medular sor anaplasic motivate usually the generous resction, according to the tumor, thyroidectomy sub-complete or complete.Generally, folicular tumors and papilars are of show evolution, while the anaplasic is a very malignant tumor that causes oncologic urgencias because of trachea compresión, what cause inmediate surgery.

Most of the times, it is used radiotherapy with iodine, radioactive which is very effective if there are gland remains yet. Basquade acts as a moderator of the remaining thyroid secretion if there was, preventing from distance appearance of metastasi or intra-thyroid, this is done by an endocrine action which makes us think in an action mediated by hormones, in which Basquade acts as hormon-like allowing to maintain acceptable levels of thyroid and parathyroid hormones, knowing that many times in surgeries, parathyroids are removed by accident and the patient has to receive the hormones in an exogen way.

Basquade’s way of action over the tumor, if this is present, is a mixed action , antiangiogenic and direct cytotoxic altering the tumoral DNA bases as it also does in other types of tumors.

Action in vulva-vaginal neoplasias

Basqüadé acts in these neoplasias by a direct effect, as it has been already mentioned and resides it has an important role from an immune point of view preventing pre-cancerous injuries in this sector of the economy. Generally, surgery is done of tumoral exeresi and after telecobalt-therapy or brachitherapy. Many times the patients visit after the conventional therapeutic is done and the vascularization is no good.

Thsu, Basquade contributes to improve the general condition, improves appetite and physical activity, what allows a better quality of life and a longer life. There are examples of patients treated only with Basqüadé that get a clear improvement, however if it is used after convencional therapy its action doesn’t contribute with the one of other treatments.

To sum up, Basqüadé acts in theses neoplasias by the already explained mechanisms, cytotoxic direct action , inhibition of the neo-vascularization, increase in immunity, anti-infectious activity and an anabolizing action that takes to an improvement in the terrain and thus to the general condition.

Action in breast neoplasias

Basqüadé®’s action has been thoroughly studied in breast cancer.
Basqüadé® acts directly on the tumoral cell, causing a hormonal blocking and taking the neoplasic cells to death. Besides of its antiangiogenic effect it is added a hormonal effect, because this cancer is very linked to women’s hormonal oscilations and in a hundredth part of men.

Basqüadé® diverts the methabolism of the cancerous cells causin a cell “suicide” that diminishes in anotorious way the tumor’s size and besides the amount of active cells, and this way allows to take convencional treatments over a smaller substratum and this way it multiplies its efficiency.

Big tumors have considerably diminished by Basquade’s action and could be removed by surgery and after treated with radium and chimiotherapy, what has allowed the complete healing of the patient and a standard life expectation. Basqüadé®, as it is also an inmunomodulator, modulates the blood elements trying to prevent that if there is a conventional treatment, leucopenias or anaemia acould appear, what not always is posible but in a high percentage it is. It improves the patient’s mood, what allows daily activities.

Action in skin neoplasias

Basqüadé acts in the skin neoplasias by a repairing mechanism of the injury or the place where it was if this was already removed. It is used orally so it can act in the systemic way getting to the injury and acting over it causing cytolisis., increasing immunity and causing an anti-neoplasic action by immunomodulator effect. It is also used the Basqüadé Gel concomitantly that penetrates through the skin layers in order to act directly on the tumoral focal point and allow a lasting healing of the skin.

The Gel penetrates easily the different layers and easily goes to the cancerous focal point, eliminating it by the same effects that by systemic way. It acts on the tumor causing the desaferentization of the neo-vascular jumbling up the nuclear DNA , actino on its bases and by cytotoxic direct action penetrating the tumoral cell membrana, altering the membrane potentials.

Action in hepatic secondarism

The hepatic parenquime is very wide and is one of the places where the economy gets most metastized, being a filter for the metastasi in different places of the body where the neoplasias occur. Basqüadé®’s action takes place directly on the neo-vascularization that occurs in every metastasi, depriving it of oxygen transported by the neo-vessels.

This causes an important reduce of the metastasi and the same time changes that contribute to the death of the cells that lie there.
We have to take into account that the most resistant clones are the ones that get metastasized, so many times it is controlled the prmary, not getting a good control of the metastasi at the hepatic level. However, because the liver parenchime is so big, the polimetatization at that level would be the cause in the failure of its main functions as a toxins purifier and as an exocrin gland.

Basqüadé® penetrates in the cells causing distortion in the nucleus and the cytoplasm and altering the metastasic DNA, achieving a unique effect without attacking the rest of the healthy parenchime. That’s why it is so highly efficient in the hepatic metastasi.